N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1

Mutations in the NGLY1 (N-glycanase 1) gene, encoding an evolutionarily conserved deglycosylation enzyme, are associated with a rare congenital disorder leading to global developmental delay and neurological abnormalities. The molecular mechanism of the NGLY1 disease and its function in tissue and i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Exp Med
Prif Awduron: Yang, Kun, Huang, Ryan, Fujihira, Haruhiko, Suzuki, Tadashi, Yan, Nan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2018
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170171/
https://ncbi.nlm.nih.gov/pubmed/30135079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180783
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