Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells

The cytoplasmic peptide:N-glycanase (PNGase; Ngly1 in mice) is a deglycosylating enzyme involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) process. The precise role of Ngly1 in the ERAD process, however, remains unclear in mammals. The findings reported herein, using mouse embr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Huang, Chengcheng, Harada, Yoichiro, Hosomi, Akira, Masahara-Negishi, Yuki, Seino, Junichi, Fujihira, Haruhiko, Funakoshi, Yoko, Suzuki, Takehiro, Dohmae, Naoshi, Suzuki, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321286/
https://ncbi.nlm.nih.gov/pubmed/25605922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414593112
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