Differential effects of withdrawal from intermittent and continuous nicotine exposure on reward deficit and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in Wistar male rats

BACKGROUND: Chronic nicotine exposure produces neuroadaptations in brain reward systems and α4β2 nicotinic acetylcholine receptors (nAChRs) in the corticolimbic brain areas. We previously demonstrated opposite effects of nicotine exposure delivered by self-administration or pumps on brain reward thr...

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Publicado en:Pharmacol Biochem Behav
Main Authors: Semenova, Svetlana, Jin, Xinchun, McClure-Begley, Tristan D, Tadman, Matthew Philip, Marks, Michael J, Markou, Athina
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170027/
https://ncbi.nlm.nih.gov/pubmed/29908200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2018.06.002
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