Activation of podocyte Notch mediates early Wt1 glomerulopathy

The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of scar tissue within glomeruli, the mechanis...

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Détails bibliographiques
Publié dans:Kidney Int
Auteurs principaux: Asfahani, Rowan I., Tahoun, Mona M., Miller-Hodges, Eve V., Bellerby, Jack, Virasami, Alex K., Sampson, Robert D., Moulding, Dale, Sebire, Neil J., Hohenstein, Peter, Scambler, Peter J., Waters, Aoife M.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6169130/
https://ncbi.nlm.nih.gov/pubmed/29398135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.11.014
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