The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-β1–Mediated Biliary Senescence

Activation of the secretin (Sct)/secretin receptor (SR) axis stimulates ductular reaction and liver fibrosis, which are hallmarks of cholangiopathies. Our aim was to define the role of Sct-regulated cellular senescence, and we demonstrated that both ductular reaction and liver fibrosis are significa...

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Détails bibliographiques
Publié dans:Am J Pathol
Auteurs principaux: Wu, Nan, Meng, Fanyin, Zhou, Tianhao, Venter, Julie, Giang, Thao K., Kyritsi, Konstantina, Wu, Chaodong, Alvaro, Domenico, Onori, Paolo, Mancinelli, Romina, Gaudio, Eugenio, Francis, Heather, Alpini, Gianfranco, Glaser, Shannon, Franchitto, Antonio
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168967/
https://ncbi.nlm.nih.gov/pubmed/30036520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.06.015
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