The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF-β1 biliary secretion

The secretin/secretin receptor (SR) axis is upregulated by proliferating cholangiocytes during cholestasis. Secretin stimulates biliary proliferation by downregulation of let-7a and subsequent upregulation of the growth-promoting factor NGF. It is not know if the secretin/SR axis plays a role in sub...

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Veröffentlicht in:Hepatology
Hauptverfasser: Wu, Nan, Meng, Fanyin, Invernizzi, Pietro, Bernuzzi, Francesca, Venter, Julie, Standeford, Holly, Onori, Paolo, Marzioni, Marco, Alvaro, Domenico, Franchitto, Antonio, Gaudio, Eugenio, Glaser, Shannon, Alpini, Gianfranco
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4992423/
https://ncbi.nlm.nih.gov/pubmed/27115285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28622
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