Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(−/−) mice by diminishing senescence of cholangiocytes

Secretin receptor (SR), only expressed by cholangiocytes, plays a key role in the regulation of biliary damage and liver fibrosis. The aim of this study was to determine the effects of genetic depletion of SR in Mdr2(−/−) mice on intrahepatic biliary mass, liver fibrosis, senescence and angiogenesis...

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Publicado en:Lab Invest
Autores principales: Zhou, Tianhao, Wu, Nan, Meng, Fanyin, Venter, Julie, Giang, Thao K, Francis, Heather, Kyritsi, Konstantina, Wu, Chaodong, Franchitto, Antonio, Alvaro, Domenico, Marzioni, Marco, Onori, Paolo, Mancinelli, Romina, Gaudio, Eugenio, Glaser, Shannon, Alpini, Gianfranco
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214714/
https://ncbi.nlm.nih.gov/pubmed/29977037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-018-0093-9
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