A PHASE I EXPANSION STUDY OF PEGARGIMINASE, CISPLATIN AND PEMETREXED IN ARGININOSUCCINATE SYNTHETASE 1-NEGATIVE RECURRENT HIGH GRADE GLIOMAS (HGGS)

BACKGROUND: Patients (pts) with recurrent HGGs are usually managed with alkylating chemotherapy +/- bevacizumab. However, prognosis remains poor with an overall survival (OS) of 7–9 months. Preclinically, we showed that HGGs are a target for arginine depletion with Pegargiminase (ADI-PEG20) due to e...

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Vydáno v:Neuro Oncol
Hlavní autoři: Hall, Peter, Lewis, Rachel, Syed, Nelofer, Shaffer, Richard, Evanson, Jane, Ellis, Stephen, Williams, Matthew, Feng, Xiaoxing, Johnston, Amanda, Thomson, Jim, Harris, Fiona, Jena, Raj, Jefferies, Sarah, Khadeir, Ramsay, Wu, Bor-Wen, Bomalaski, John, Crook, Timothy, Sheaff, Michael, Pacey, Simon, Plowman, Nick, Szlosarek, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168855/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy129.003
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