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Allosteric Role of Substrate Occupancy Toward the Alignment of P-glycoprotein Nucleotide Binding Domains

P-glycoprotein (Pgp) is an ATP-binding cassette transporter that eliminates toxins from the cell but causes multidrug resistance in chemotherapies. The crystal structures of Pgp revealed drug-like compounds bound to an inward-facing conformation in which the energy-harnessing nucleotide binding doma...

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Сохранить в:
Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Pan, Lurong, Aller, Stephen G.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168518/
https://ncbi.nlm.nih.gov/pubmed/30279588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32815-2
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