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An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back
The Hsp70 is an allosterically regulated family of molecular chaperones. They consist of two structural domains, NBD and SBD, connected by a flexible linker. ATP hydrolysis at the NBD modulates substrate recognition at the SBD, while peptide binding at the SBD enhances ATP hydrolysis. In this study...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4812256/ https://ncbi.nlm.nih.gov/pubmed/27025773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23474 |
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