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An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back

The Hsp70 is an allosterically regulated family of molecular chaperones. They consist of two structural domains, NBD and SBD, connected by a flexible linker. ATP hydrolysis at the NBD modulates substrate recognition at the SBD, while peptide binding at the SBD enhances ATP hydrolysis. In this study...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Chiappori, Federica, Merelli, Ivan, Milanesi, Luciano, Colombo, Giorgio, Morra, Giulia
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4812256/
https://ncbi.nlm.nih.gov/pubmed/27025773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep23474
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