Small GTPases SAR1A and SAR1B regulate the trafficking of the cardiac sodium channel Na(v)1.5

BACKGROUND: The cardiac sodium channel Na(v)1.5 is essential for the physiological function of the heart and causes cardiac arrhythmias and sudden death when mutated. Many disease-causing mutations in Na(v)1.5 cause defects in protein trafficking, a cellular process critical to the targeting of Na(v...

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Publié dans:Biochim Biophys Acta Mol Basis Dis
Auteurs principaux: Wang, Zhijie, Yu, Gang, Liu, Yinan, Liu, Shiyong, Aridor, Meir, Huang, Yuan, Hu, Yushuang, Wang, Longfei, Li, Sisi, Xiong, Hongbo, Tang, Bo, Li, Xia, Cheng, Chen, Chakrabarti, Susmita, Wang, Fan, Wu, Qingyu, Karnik, Sadashiva S., Xu, Chengqi, Chen, Qiuyun, Wang, Qing K.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168416/
https://ncbi.nlm.nih.gov/pubmed/30251687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2018.09.003
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