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Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na(v)1.5 clarify the molecular basis of Brugada syndrome
Na(v)1.5 is the α-subunit of the cardiac sodium channel complex. Abnormal expression of Na(v)1.5 on the cell surface because of mutations that disrupt Na(v)1.5 trafficking causes Brugada syndrome (BrS), sick sinus syndrome (SSS), cardiac conduction disease, dilated cardiomyopathy, and sudden infant...
Kaydedildi:
| Yayımlandı: | J Biol Chem |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6254340/ https://ncbi.nlm.nih.gov/pubmed/30282806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003997 |
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