Mechanistic insights into the interaction of the MOG1 protein with the cardiac sodium channel Na(v)1.5 clarify the molecular basis of Brugada syndrome

Na(v)1.5 is the α-subunit of the cardiac sodium channel complex. Abnormal expression of Na(v)1.5 on the cell surface because of mutations that disrupt Na(v)1.5 trafficking causes Brugada syndrome (BrS), sick sinus syndrome (SSS), cardiac conduction disease, dilated cardiomyopathy, and sudden infant...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yu, Gang, Liu, Yinan, Qin, Jun, Wang, Zhijie, Hu, Yushuang, Wang, Fan, Li, Yabo, Chakrabarti, Susmita, Chen, Qiuyun, Wang, Qing Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6254340/
https://ncbi.nlm.nih.gov/pubmed/30282806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003997
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