Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality

PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investigate its physiological relevance. Pich KO mice lose viability...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Albers, Eliene, Sbroggiò, Mauro, Pladevall-Morera, David, Bizard, Anna H., Avram, Alexandra, Gonzalez, Patricia, Martin-Gonzalez, Javier, Hickson, Ian D., Lopez-Contreras, Andres J.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167640/
https://ncbi.nlm.nih.gov/pubmed/30232008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.071
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