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Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses
Mouse Cx50D47A and human Cx50D47N are non-functional connexin mutants that cause dominantly-inherited cataracts. In tissue culture expression experiments, they both exhibit impaired cellular trafficking and gap junction plaque formation. Lenses of mice expressing Cx50D47A have cataracts, reduced siz...
Gardado en:
| Publicado en: | Exp Eye Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6167189/ https://ncbi.nlm.nih.gov/pubmed/29913165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.06.015 |
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