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Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses

Mouse Cx50D47A and human Cx50D47N are non-functional connexin mutants that cause dominantly-inherited cataracts. In tissue culture expression experiments, they both exhibit impaired cellular trafficking and gap junction plaque formation. Lenses of mice expressing Cx50D47A have cataracts, reduced siz...

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Bibliografiske detaljer
Udgivet i:Exp Eye Res
Main Authors: Jara, Oscar, Minogue, Peter J., Berthoud, Viviana M., Beyer, Eric C.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167189/
https://ncbi.nlm.nih.gov/pubmed/29913165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.06.015
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