Correcting the Mean-Variance Dependency for Differential Variability Testing Using Single-Cell RNA Sequencing Data

Cell-to-cell transcriptional variability in otherwise homogeneous cell populations plays an important role in tissue function and development. Single-cell RNA sequencing can characterize this variability in a transcriptome-wide manner. However, technical variation and the confounding between variabi...

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Publicado en:Cell Syst
Main Authors: Eling, Nils, Richard, Arianne C., Richardson, Sylvia, Marioni, John C., Vallejos, Catalina A.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167088/
https://ncbi.nlm.nih.gov/pubmed/30172840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.06.011
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