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Beyond comparisons of means: understanding changes in gene expression at the single-cell level

Traditional differential expression tools are limited to detecting changes in overall expression, and fail to uncover the rich information provided by single-cell level data sets. We present a Bayesian hierarchical model that builds upon BASiCS to study changes that lie beyond comparisons of means,...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Vallejos, Catalina A., Richardson, Sylvia, Marioni, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832562/
https://ncbi.nlm.nih.gov/pubmed/27083558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-0930-3
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