Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy

In gene therapy for Duchenne muscular dystrophy there are two potential immunological obstacles. An individual with Duchenne muscular dystrophy has a genetic mutation in dystrophin, and therefore the wild-type protein is “foreign,” and thus potentially immunogenic. The adeno-associated virus serotyp...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Ho, Peggy P., Lahey, Lauren J., Mourkioti, Foteini, Kraft, Peggy E., Filareto, Antonio, Brandt, Moritz, Magnusson, Klas E. G., Finn, Eric E., Chamberlain, Jeffrey S., Robinson, William H., Blau, Helen M., Steinman, Lawrence
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2018
विषय:
PNAS Plus
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166850/
https://ncbi.nlm.nih.gov/pubmed/30181272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808648115
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