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Structural basis for activation of voltage sensor domains in an ion channel TPC1
Voltage-sensing domains (VSDs) couple changes in transmembrane electrical potential to conformational changes that regulate ion conductance through a central channel. Positively charged amino acids inside each sensor cooperatively respond to changes in voltage. Our previous structure of a TPC1 chann...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166827/ https://ncbi.nlm.nih.gov/pubmed/30190435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805651115 |
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