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Mitochondrial methionyl N-formylation affects steady-state levels of oxidative phosphorylation complexes and their organization into supercomplexes

N-Formylation of the Met-tRNA(Met) by the nuclearly encoded mitochondrial methionyl-tRNA formyltransferase (MTFMT) has been found to be a key determinant of protein synthesis initiation in mitochondria. In humans, mutations in the MTFMT gene result in Leigh syndrome, a progressive and severe neurome...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Arguello, Tania, Köhrer, Caroline, RajBhandary, Uttam L., Moraes, Carlos T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166738/
https://ncbi.nlm.nih.gov/pubmed/30087118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003838
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