The contribution of cross-talk between the cell-surface proteins CD36 and CD47–TSP-1 in osteoclast formation and function

Antibody-mediated blockade of cluster of differentiation 47 (CD47)–thrombospondin-1 (TSP-1) interactions blocks osteoclast formation in vitro and attenuates parathyroid hormone (PTH)-induced hypercalcemia in vivo in mice. Hypercalcemia in this model reflects increased bone resorption. TSP-1 has two...

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Vydáno v:J Biol Chem
Hlavní autoři: Koduru, Srinivas V., Sun, Ben-hua, Walker, Joanne M., Zhu, Meiling, Simpson, Christine, Dhodapkar, Madhav, Insogna, Karl L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166722/
https://ncbi.nlm.nih.gov/pubmed/30082316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000633
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