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Observing Single-Molecule Dynamics at Millimolar Concentrations

Single-molecule fluorescence microscopy is a powerful tool for revealing chemical dynamics and molecular association mechanisms, but was limited to low concentrations of fluorescent species only suitable for studying high affinity reactions. Here, we combine nanophotonic zero-mode waveguides (ZMW) w...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Goldschen-Ohm, Marcel P., White, David S., Klenchin, Vadim A., Chanda, Baron, Goldsmith, Randall H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166642/
https://ncbi.nlm.nih.gov/pubmed/28116856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201612050
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