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Loss of PDK4 switches the hepatic NF-κB/TNF pathway from pro-survival to pro-apoptosis
It has been established that NF-κB members promote survival by upregulating anti-apoptotic genes and that genetic and pharmacological inhibition of NF-κB is required for TNF-induced hepatocyte apoptosis. In this study, we demonstrate that this pro-survival pathway is switched to pro-apoptosis under...
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| Pubblicato in: | Hepatology |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6165716/ https://ncbi.nlm.nih.gov/pubmed/29603325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29902 |
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