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Loss of PDK4 switches the hepatic NF-κB/TNF pathway from pro-survival to pro-apoptosis

It has been established that NF-κB members promote survival by upregulating anti-apoptotic genes and that genetic and pharmacological inhibition of NF-κB is required for TNF-induced hepatocyte apoptosis. In this study, we demonstrate that this pro-survival pathway is switched to pro-apoptosis under...

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書目詳細資料
發表在:Hepatology
Main Authors: Wu, Jianguo, Zhao, Yulan, Park, Young-Ki, Lee, Ji-Young, Gao, Ling, Zhao, Jiajun, Wang, Li
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6165716/
https://ncbi.nlm.nih.gov/pubmed/29603325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29902
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