GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling

Huntington’s disease (HD) is a progressive and fatal neurodegenerative disease caused by CAG repeat expansion in the coding region of huntingtin (HTT) protein. The accumulation of mutant HTT (mHTT) contributes to neurotoxicity by causing autophagy defects and oxidative stress that ultimately lead to...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Chang, Ching-Chi, Lin, Tzu-Chin, Ho, Hsiao-Li, Kuo, Chien-Yin, Li, Hsin-Hua, Korolenko, Tatiana A., Chen, Wei-Jen, Lai, Te-Jen, Ho, Ying-Jui, Lin, Chih-Li
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6164932/
https://ncbi.nlm.nih.gov/pubmed/30149534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092505
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