Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide

AIMS: To compare the pharmacokinetics (PK) of a single-dose of liraglutide in subjects with hepatic impairment. METHODS: This parallel group, open label trial involved four groups of six subjects with healthy, mild, moderate and severe hepatic impairment, respectively. Each subject received 0.75 mg...

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Autores principales: Flint, Anne, Nazzal, Khalil, Jagielski, Pawel, Hindsberger, Charlotte, Zdravkovic, Milan
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2010
Materias:
Pharmacokinetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997321/
https://ncbi.nlm.nih.gov/pubmed/21175436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03762.x
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