Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na(+)/K(+)-ATPase Profibrotic Signaling Pathways

Cardiotonic steroids (CTS) are Na(+)/K(+)-ATPase (NKA) ligands that are elevated in volume-expanded states and associated with cardiac and renal dysfunction in both clinical and experimental settings. We test the hypothesis that the CTS telocinobufagin (TCB) promotes renal dysfunction in a process i...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Kennedy, David J., Khalaf, Fatimah K., Sheehy, Brendan, Weber, Malory E., Agatisa-Boyle, Brendan, Conic, Julijana, Hauser, Kayla, Medert, Charles M., Westfall, Kristen, Bucur, Philip, Fedorova, Olga V., Bagrov, Alexei Y., Tang, W. H. Wilson
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6164831/
https://ncbi.nlm.nih.gov/pubmed/30158457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092566
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