DigiFab Interacts With Endogenous Cardiotonic Steroids and Reverses Preeclampsia-Induced Na/K-ATPase Inhibition

Elevated levels of endogenous Na/K-ATPase (NKA) inhibitors, cardiotonic steroids (CTSs) including marinobufagenin (MBG), contribute to pathogenesis of preeclampsia (PE) and represent a target for immunoneutralization by Digibind (Ovine Digoxin Immune Antibody, Glaxo-Smith Kline). Because Digibind is...

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Bibliographic Details
Main Authors: Ishkaraeva-Yakovleva, Valentina V., Fedorova, Olga V., Solodovnikova, Nelly G., Frolova, Elena V., Bzhelyansky, Anton M., Emelyanov, Igor V., Adair, C. David, Zazerskaya, Irina E., Bagrov, Alexei Y.
Format: Artigo
Language:Inglês
Published: SAGE Publications 2012
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434252/
https://ncbi.nlm.nih.gov/pubmed/22649120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1933719112447124
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