IN PREECLAMPSIA ENDOGENOUS CARDIOTONIC STEROIDS INDUCE VASCULAR FIBROSIS AND IMPAIR RELAXATION OF UMBILICAL ARTERIES

BACKGROUND: Marinobufagenin (MBG), a bufadienolide cardiotonic steroid, induces cardiovascular fibrosis. Because levels of MBG in preeclampsia are increased, and anti-MBG monoclonal antibody reduces blood pressure (BP) in a rat model of preeclampsia, we hypothesized that in preeclampsia, elevated MB...

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Auteurs principaux: Nikitina, Elena R., Mikhailov, Anton V., Nikandrova, Ekaterina S., Frolova, Elena V., Fadeev, Artem V., Shman, Vera V., Shilova, Victoria Y., Tapilskaya, Natalia I., Shapiro, Joseph I., Fedorova, Olga V., Bagrov, Alexei Y.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053428/
https://ncbi.nlm.nih.gov/pubmed/21330936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e32834436a7
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