IN PREECLAMPSIA ENDOGENOUS CARDIOTONIC STEROIDS INDUCE VASCULAR FIBROSIS AND IMPAIR RELAXATION OF UMBILICAL ARTERIES

BACKGROUND: Marinobufagenin (MBG), a bufadienolide cardiotonic steroid, induces cardiovascular fibrosis. Because levels of MBG in preeclampsia are increased, and anti-MBG monoclonal antibody reduces blood pressure (BP) in a rat model of preeclampsia, we hypothesized that in preeclampsia, elevated MB...

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Bibliografiske detaljer
Main Authors: Nikitina, Elena R., Mikhailov, Anton V., Nikandrova, Ekaterina S., Frolova, Elena V., Fadeev, Artem V., Shman, Vera V., Shilova, Victoria Y., Tapilskaya, Natalia I., Shapiro, Joseph I., Fedorova, Olga V., Bagrov, Alexei Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053428/
https://ncbi.nlm.nih.gov/pubmed/21330936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e32834436a7
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