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Phosphorylation-Dependent Inhibition of Akt1
Protein kinase B (Akt1) is a proto-oncogene that is overactive in most cancers. Akt1 activation requires phosphorylation at Thr308; phosphorylation at Ser473 further enhances catalytic activity. Akt1 activity is also regulated via interactions between the kinase domain and the N-terminal auto-inhibi...
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| Publié dans: | Genes (Basel) |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
MDPI
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6162393/ https://ncbi.nlm.nih.gov/pubmed/30205513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes9090450 |
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