Methylation of Structured RNA by the m(6)A Writer METTL16 Is Essential for Mouse Embryonic Development

Internal modification of RNAs with N(6)-methyladenosine (m(6)A) is a highly conserved means of gene expression control. While the METTL3/METTL14 heterodimer adds this mark on thousands of transcripts in a single-stranded context, the substrate requirements and physiological roles of the second m(6)A...

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Udgivet i:Mol Cell
Main Authors: Mendel, Mateusz, Chen, Kuan-Ming, Homolka, David, Gos, Pascal, Pandey, Radha Raman, McCarthy, Andrew A., Pillai, Ramesh S.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162343/
https://ncbi.nlm.nih.gov/pubmed/30197299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.004
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