Splice site m(6)A methylation prevents binding of U2AF35 to inhibit RNA splicing

The N(6)-methyladenosine (m(6)A) RNA modification is used widely to alter the fate of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse METTL16) deposits an m(6)A mark on the 3′ splice site (AG) of the S-adenosylmethionine (SAM) synthetase pre-mRNA, which inhibits...

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Pubblicato in:Cell
Autori principali: Mendel, Mateusz, Delaney, Kamila, Pandey, Radha Raman, Chen, Kuan-Ming, Wenda, Joanna M., Vågbø, Cathrine Broberg, Steiner, Florian A., Homolka, David, Pillai, Ramesh S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208822/
https://ncbi.nlm.nih.gov/pubmed/33930289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.03.062
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