Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function

Small RNAs called PIWI-interacting RNAs (piRNAs) act as an immune system to suppress transposable elements in the animal gonads. A poorly understood adaptive pathway links cytoplasmic slicing of target RNA by the PIWI protein MILI to loading of target-derived piRNAs into nuclear MIWI2. Here we demon...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Wenda, Joanna M., Homolka, David, Yang, Zhaolin, Spinelli, Pietro, Sachidanandam, Ravi, Pandey, Radha Raman, Pillai, Ramesh S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481186/
https://ncbi.nlm.nih.gov/pubmed/28633017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.05.021
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