Systematic approach demonstrates enrichment of multiple interactions between non-HLA risk variants and HLA-DRB1 risk alleles in rheumatoid arthritis

OBJECTIVE: In anti-citrullinated protein antibody positive rheumatoid arthritis (ACPA-positive RA), a particular subset of HLA-DRB1 alleles, called shared epitope (SE) alleles, is a highly influential genetic risk factor. Here, we investigated whether non-HLA single nucleotide polymorphisms (SNP), c...

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Dettagli Bibliografici
Pubblicato in:Ann Rheum Dis
Autori principali: Diaz-Gallo, Lina-Marcela, Ramsköld, Daniel, Shchetynsky, Klementy, Folkersen, Lasse, Chemin, Karine, Brynedal, Boel, Uebe, Steffen, Okada, Yukinori, Alfredsson, Lars, Klareskog, Lars, Padyukov, Leonid
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2018
Soggetti:
Basic and Translational Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161669/
https://ncbi.nlm.nih.gov/pubmed/29967194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2018-213412
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