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Gene-environment interaction between DRB1 shared epitope and smoking regarding risk of ACPA-positive rheumatoid arthritis - all alleles are important

OBJECTIVE: An interaction effect for developing Rheumatoid Arthritis (RA) was previously observed between HLA-DRB1 shared epitope (SE) alleles and smoking. We aimed to further investigate this interaction between distinct SE alleles and smoking regarding risk of developing RA with and without antibo...

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Detalhes bibliográficos
Main Authors: Lundsröm, Emeli, Källberg, Henrik, Alfredsson, Lars, Klareskog, Lars, Padyukov, Leonid
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732897/
https://ncbi.nlm.nih.gov/pubmed/19479873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24572
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