T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

BACKGROUND: Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of th...

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Bibliografske podrobnosti
izdano v:Genome Med
Main Authors: Clarke, Erik L., Connell, A. Jesse, Six, Emmanuelle, Kadry, Nadia A., Abbas, Arwa A., Hwang, Young, Everett, John K., Hofstaedter, Casey E., Marsh, Rebecca, Armant, Myriam, Kelsen, Judith, Notarangelo, Luigi D., Collman, Ronald G., Hacein-Bey-Abina, Salima, Kohn, Donald B., Cavazzana, Marina, Fischer, Alain, Williams, David A., Pai, Sung-Yun, Bushman, Frederic D.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161392/
https://ncbi.nlm.nih.gov/pubmed/30261899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0580-z
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