T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

BACKGROUND: Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of th...

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Détails bibliographiques
Publié dans:Genome Med
Auteurs principaux: Clarke, Erik L., Connell, A. Jesse, Six, Emmanuelle, Kadry, Nadia A., Abbas, Arwa A., Hwang, Young, Everett, John K., Hofstaedter, Casey E., Marsh, Rebecca, Armant, Myriam, Kelsen, Judith, Notarangelo, Luigi D., Collman, Ronald G., Hacein-Bey-Abina, Salima, Kohn, Donald B., Cavazzana, Marina, Fischer, Alain, Williams, David A., Pai, Sung-Yun, Bushman, Frederic D.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161392/
https://ncbi.nlm.nih.gov/pubmed/30261899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0580-z
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