T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

BACKGROUND: Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene therapy. SCID-X1 gene therapy results in reconstitution of the previously lacking T cell compartment, allowing analysis of th...

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Detalhes bibliográficos
Publicado no:Genome Med
Main Authors: Clarke, Erik L., Connell, A. Jesse, Six, Emmanuelle, Kadry, Nadia A., Abbas, Arwa A., Hwang, Young, Everett, John K., Hofstaedter, Casey E., Marsh, Rebecca, Armant, Myriam, Kelsen, Judith, Notarangelo, Luigi D., Collman, Ronald G., Hacein-Bey-Abina, Salima, Kohn, Donald B., Cavazzana, Marina, Fischer, Alain, Williams, David A., Pai, Sung-Yun, Bushman, Frederic D.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161392/
https://ncbi.nlm.nih.gov/pubmed/30261899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0580-z
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