Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

BACKGROUND/OBJECTIVE: Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in the liver. Animal studies have revealed insulin signaling favoring gluconeogenesis suppression to be selectively impaired in steatotic livers. However, whe...

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Bibliografske podrobnosti
izdano v:Int J Obes (Lond)
Main Authors: Honma, Midori, Sawada, Shojiro, Ueno, Yoshiyuki, Murakami, Keigo, Yamada, Tetsuya, Gao, Junhong, Kodama, Shinjiro, Izumi, Tomohito, Takahashi, Kei, Tsukita, Sohei, Uno, Kenji, Imai, Junta, Kakazu, Eiji, Kondo, Yasuteru, Mizuno, Kei, Kawagishi, Naoki, Shimosegawa, Tooru, Katagiri, Hideki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160396/
https://ncbi.nlm.nih.gov/pubmed/29717275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-018-0062-9
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