Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

BACKGROUND/OBJECTIVE: Insulin signals, via the regulation of key enzyme expression, both suppress gluconeogenesis and enhance lipid synthesis in the liver. Animal studies have revealed insulin signaling favoring gluconeogenesis suppression to be selectively impaired in steatotic livers. However, whe...

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Detalhes bibliográficos
Publicado no:Int J Obes (Lond)
Main Authors: Honma, Midori, Sawada, Shojiro, Ueno, Yoshiyuki, Murakami, Keigo, Yamada, Tetsuya, Gao, Junhong, Kodama, Shinjiro, Izumi, Tomohito, Takahashi, Kei, Tsukita, Sohei, Uno, Kenji, Imai, Junta, Kakazu, Eiji, Kondo, Yasuteru, Mizuno, Kei, Kawagishi, Naoki, Shimosegawa, Tooru, Katagiri, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160396/
https://ncbi.nlm.nih.gov/pubmed/29717275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-018-0062-9
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