Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

Most bacteria use an indirect pathway to generate aminoacylated glutamine and/or asparagine tRNAs. Clinical isolates of Mycobacterium tuberculosis with increased rates of error in gene translation (mistranslation) involving the indirect tRNA-aminoacylation pathway have increased tolerance to the fir...

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Bibliographic Details
Published in:eLife
Main Authors: Chaudhuri, Swarnava, Li, Liping, Zimmerman, Matthew, Chen, Yuemeng, Chen, Yu-Xiang, Toosky, Melody N, Gardner, Michelle, Pan, Miaomiao, Li, Yang-Yang, Kawaji, Qingwen, Zhu, Jun-Hao, Su, Hong-Wei, Martinot, Amanda J, Rubin, Eric J, Dartois, Veronique Anne, Javid, Babak
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Microbiology and Infectious Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160228/
https://ncbi.nlm.nih.gov/pubmed/30152756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36782
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