MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

Inflammatory β-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Pro-inflammatory cytokines cause β-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent β-cell failure in vitro and in vivo, in part by reducing NF-κB transcriptional activity. We investi...

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Veröffentlicht in:PLoS One
Hauptverfasser: Lindeløv Vestergaard, Anna, Heiner Bang-Berthelsen, Claus, Fløyel, Tina, Lucien Stahl, Jonathan, Christen, Lisa, Taheri Sotudeh, Farzaneh, de Hemmer Horskjær, Peter, Stensgaard Frederiksen, Klaus, Greek Kofod, Frida, Bruun, Christine, Adrian Berchtold, Lukas, Størling, Joachim, Regazzi, Romano, Kaur, Simranjeet, Pociot, Flemming, Mandrup-Poulsen, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160007/
https://ncbi.nlm.nih.gov/pubmed/30260972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203713
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