MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage

Inflammatory β-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Pro-inflammatory cytokines cause β-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent β-cell failure in vitro and in vivo, in part by reducing NF-κB transcriptional activity. We investi...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lindeløv Vestergaard, Anna, Heiner Bang-Berthelsen, Claus, Fløyel, Tina, Lucien Stahl, Jonathan, Christen, Lisa, Taheri Sotudeh, Farzaneh, de Hemmer Horskjær, Peter, Stensgaard Frederiksen, Klaus, Greek Kofod, Frida, Bruun, Christine, Adrian Berchtold, Lukas, Størling, Joachim, Regazzi, Romano, Kaur, Simranjeet, Pociot, Flemming, Mandrup-Poulsen, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160007/
https://ncbi.nlm.nih.gov/pubmed/30260972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203713
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