Endothelial pyruvate kinase M2 maintains vascular integrity

The M2 isoform of pyruvate kinase (PKM2) is highly expressed in most cancer cells, and has been studied extensively as a driver of oncogenic metabolism. In contrast, the role of PKM2 in nontransformed cells is little studied, and nearly nothing is known of its role, if any, in quiescent cells. We sh...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Kim, Boa, Jang, Cholsoon, Dharaneeswaran, Harita, Li, Jian, Bhide, Mohit, Yang, Steven, Li, Kristina, Arany, Zolt
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159968/
https://ncbi.nlm.nih.gov/pubmed/30222136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120912
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