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Mitochondria cripple without Krüppel
Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance via regulation of mitophagy. Disruption of KLF4 leads to profo...
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| Pubblicato in: | Trends Endocrinol Metab |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4797320/ https://ncbi.nlm.nih.gov/pubmed/26404663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2015.08.004 |
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