Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

Polyamine inhibition for cancer therapy is, conceptually, an attractive approach but has yet to meet success in the clinical setting. The aryl hydrocarbon receptor (AHR) is the central transcriptional regulator of the xenobiotic response. Our study revealed that AHR also positively regulates intrace...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bianchi-Smiraglia, Anna, Bagati, Archis, Fink, Emily E., Affronti, Hayley C., Lipchick, Brittany C., Moparthy, Sudha, Long, Mark D., Rosario, Spencer R., Lightman, Shivana M., Moparthy, Kalyana, Wolff, David W., Yun, Dong Hyun, Han, Zhannan, Polechetti, Anthony, Roll, Matthew V., Gitlin, Ilya I., Leonova, Katerina I., Rowsam, Aryn M., Kandel, Eugene S., Gudkov, Andrei V., Bergsagel, P. Leif, Lee, Kelvin P., Smiraglia, Dominic J., Nikiforov, Mikhail A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159960/
https://ncbi.nlm.nih.gov/pubmed/30198908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70712
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