XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

Transcription factor XBP1s, activated by endoplasmic reticulum (ER) stress in a dose-dependent manner, plays a central role in adaptive unfolded protein response (UPR) via direct activation of multiple genes controlling protein refolding. Here, we report that elevation of ER stress above a critical...

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Publicado no:Cell Rep
Main Authors: Fink, Emily E., Moparthy, Sudha, Bagati, Archis, Bianchi-Smiraglia, Anna, Lipchick, Brittany C., Wolff, David W., Roll, Matthew V., Wang, Jianmin, Liu, Song, Bakin, Andrei V., Kandel, Eugene S., Lee, Ann-Hwee, Nikiforov, Mikhail A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251307/
https://ncbi.nlm.nih.gov/pubmed/30282030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.013
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