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Alterations of functional circuitry in aging brain and the impact of mutated APP expression

Alzheimer's disease (AD) is a disease of aging that results in cognitive impairment, dementia and death. Pathognomonic features of AD are amyloid plaques composed of proteolytic fragments of the amyloid precursor protein (APP) and neurofibrillary tangles composed of hyperphosphorylated tau prot...

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Detalhes bibliográficos
Publicado no:Neurobiol Aging
Main Authors: Bearer, Elaine L., Manifold-Wheeler, Brett C., Medina, Christopher S., Gonzales, Aaron, Cháves, Frances, Jacobs, Russell E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6159914/
https://ncbi.nlm.nih.gov/pubmed/30055413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2018.06.018
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