CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway

BACKGROUND: In colorectal cancer, CDX2 expression is lost in approximately 20% of cases and associated with poor outcome. Here, we aim to validate the clinical impact of CDX2 and investigate the role of promoter methylation and histone deacetylation in CDX2 repression and restoration. METHODS: CDX2...

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Bibliografiske detaljer
Udgivet i:Clin Epigenetics
Main Authors: Graule, Janina, Uth, Kristin, Fischer, Elia, Centeno, Irene, Galván, José A., Eichmann, Micha, Rau, Tilman T., Langer, Rupert, Dawson, Heather, Nitsche, Ulrich, Traeger, Peter, Berger, Martin D., Schnüriger, Beat, Hädrich, Marion, Studer, Peter, Inderbitzin, Daniel, Lugli, Alessandro, Tschan, Mario P., Zlobec, Inti
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158822/
https://ncbi.nlm.nih.gov/pubmed/30257705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0548-2
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