CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway

BACKGROUND: In colorectal cancer, CDX2 expression is lost in approximately 20% of cases and associated with poor outcome. Here, we aim to validate the clinical impact of CDX2 and investigate the role of promoter methylation and histone deacetylation in CDX2 repression and restoration. METHODS: CDX2...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Graule, Janina, Uth, Kristin, Fischer, Elia, Centeno, Irene, Galván, José A., Eichmann, Micha, Rau, Tilman T., Langer, Rupert, Dawson, Heather, Nitsche, Ulrich, Traeger, Peter, Berger, Martin D., Schnüriger, Beat, Hädrich, Marion, Studer, Peter, Inderbitzin, Daniel, Lugli, Alessandro, Tschan, Mario P., Zlobec, Inti
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158822/
https://ncbi.nlm.nih.gov/pubmed/30257705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-018-0548-2
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