Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody–drug conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-associated antigens—but the multi-day half-life of ADC leads to high exposure even of normal, antigen-free, tissues...

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書誌詳細
出版年:Protein Eng Des Sel
主要な著者: Lipovšek, Daša, Carvajal, Irvith, Allentoff, Alban J, Barros, Anthony, Brailsford, John, Cong, Qiang, Cotter, Pete, Gangwar, Sanjeev, Hollander, Cris, Lafont, Virginie, Lau, Wai Leung, Li, Wenying, Moreta, Miguel, O’Neil, Steven, Pinckney, Jason, Smith, Michael J, Su, Julie, Terragni, Christina, Wallace, Michael A, Wang, Lifei, Wright, Martin, Marsh, H Nicholas, Bryson, James W
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158766/
https://ncbi.nlm.nih.gov/pubmed/30247737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy013
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