Adnectin–drug conjugates for Glypican-3-specific delivery of a cytotoxic payload to tumors

Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody–drug conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-associated antigens—but the multi-day half-life of ADC leads to high exposure even of normal, antigen-free, tissues...

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Detalhes bibliográficos
Publicado no:Protein Eng Des Sel
Main Authors: Lipovšek, Daša, Carvajal, Irvith, Allentoff, Alban J, Barros, Anthony, Brailsford, John, Cong, Qiang, Cotter, Pete, Gangwar, Sanjeev, Hollander, Cris, Lafont, Virginie, Lau, Wai Leung, Li, Wenying, Moreta, Miguel, O’Neil, Steven, Pinckney, Jason, Smith, Michael J, Su, Julie, Terragni, Christina, Wallace, Michael A, Wang, Lifei, Wright, Martin, Marsh, H Nicholas, Bryson, James W
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158766/
https://ncbi.nlm.nih.gov/pubmed/30247737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzy013
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